Fact Sheets

GAFFI Priority Fungal infections

GAFFI has identified several fungal infections as its highest priorities. Three are primarily complications of AIDS and immunosuppression (cryptococcal meningitis, Pneumocystis pneumonia and disseminated histoplasmosis) and one is a complication of tuberculosis and other lung diseases (chronic pulmonary aspergillosis). The others occur in those with normal immune systems and are ‘implantation mycoses’ or injury related and occur primarily in tropical countries, so are NTDs. More general information on NTDs can be found here. For more detailed information, please download the fact sheets below.
For more information on the “Hidden Crisis” of fungal diseases view here.


Cryptococcal meningitis Fact Sheet

Cryptococcal meningitis in AIDS (100% mortality undiagnosed and untreated, >75% survival with best treatment)

Download Here

Disseminated histoplasmosis Fact Sheet

Disseminated histoplasmosis especially in AIDS (most common in the Americas) (100% mortality undiagnosed and untreated, >90% survival with best treatment)

Download here

Pneumocystis pneumonia Fact Sheet

Pneumocystis pneumonia in AIDS, cancer and other groups (100% mortality undiagnosed and untreated, >80% survival with best treatment)

Download here

Chronic pulmonary aspergillosis Fact Sheet

Chronic pulmonary aspergillosis following TB and other pulmonary diseases (slowly progressive, destructive lung infection with high morbidity, ~15% annual mortality, over 60% response with oral therapy)

Download here

Neglected Tropical Fungal Diseases [NTFDs]


Fungal keratitis Fact Sheet

Fungal keratitis following eye injury (if untreated usually leads to blindness, 75% visual recovery with antifungal treatment of mild/moderate infection)

Download here

Chromoblastomycosis Fact Sheet

Chromobastomycosis (chromo) a neglected tropical skin disease of poor agricultural workers and curable in the early stages

Download 2018   Application to the WHO for adoption as an NTD

Daniel Wagner C. L. Santos 2021. The global burden of chromoblastomycosis PLoS Negl Trop Dis. Supplementary data.


Sporotrichosis Fact Sheet

Sporotrichosis (“gardeners” disease) is a broad term used to describe a chronic granulomatous fungal disease, mainly of the skin and lymphatic vessels acquired through traumatic inoculation (implantation mycosis) or by inhalation of conidia

Download 2018   


Mycetoma Fact Sheet

Mycetoma is a deep subcutaneous and bone disease characterised by massive deformities and disabilities with an enormous negative impact on patients and communities.

Download 2018

Emery D & Denning DW (2020) The global distribution of actinomycetoma and eumycetoma. PLoS Negl Trop Dis. Supplementary data.


Paracoccidioidomycosis Fact Sheet

Paracoccidioidomycosis (PCM) is a systemic endemic mycoses with important morbidity and mortality in Latin America, from Mexico to Argentina.

Download 2018