Cryptococcal meningitis probably now accounts for 19% of AIDS deaths

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Despite remarkable progress in treating more people with HIV infection, an estimated 4.3 million are still at risk of life-threatening fungal, bacterial and viral opportunistic infections, along with TB. In some parts of the world, cryptococcal meningitis is a major killer in AIDS. The third global estimate of cryptococcal disease, including meningitis, has just been… Read more »

Ghananian researchers find there is a new leading fungal killer in AIDS patients in West Africa

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A new study in Ghana has revealed that there are twice as many life-threatening patients with disseminated histoplasmosis (4.7%) as cryptococcal meningitis (2%) in people with HIV infection. Bright Ocansey and colleagues at Korle-Bu Teaching Hospital in Accra and Juaboso Government Hospital in Western North Ghana recruited 150 patients and tested for Histoplasma antigen in urine… Read more »

Skin NTDs – WHO launches its Strategic Framework

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  More than half of Neglected Tropical Diseases present with skin problems, and this includes 3 that are fungal – Mycetoma, Chromoblastomycosis and Sporotrichosis. On June 8th the World Health Organization launched its strategic framework for the integrated approach to these. The strategic framework is designed to assist endemic countries in reducing the morbidity, disability and… Read more »

Global fungal health advocacy organisation launches Cryptococcal Meningitis care dashboard for Africa

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Today, Global Action For Fungal Infections (GAFFI) released a visual dashboard showing the capacity for high-quality care for cryptococcal meningitis in each country in Africa. Assembled following a continent-wide survey of diagnostic practice, the dashboard shows which countries can rapidly diagnose this life-threatening infection, and which cannot, or can do so only partially. The dashboard… Read more »

GAFFI’s Annual Report highlights enormous progress in awareness and diagnostic tools for Fungal Disease – major gaps remain

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There is no denying that it has been another tumultuous year in terms of global infectious diseases, particularly in India, which saw the world’s first major outbreak of mucormycosis affecting over 40,000 people (with COVID-19 and usually diabetes), and is the epicentre of the resistance outbreak caused by the new skin fungus Trichophyton indotineae. Despite… Read more »

Dr Tom Chiller of the CDC joins GAFFI as a Senior Advisor

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While leading the US Centre for Disease Control and Prevention (CDC) Mycotic Disease Branch, Dr Chiller has been very active in promoting rapid screening for cryptococcal meningitis and disseminated histoplasmosis in people with Advanced HIV Disease. He and his colleagues at CDC have collated US and global data on the multi-resistant fungus Candida auris and… Read more »

Single large dose of liposomal amphotericin B for cryptococcal meningitis effective  

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The world’s largest randomised study of HIV-positive adults with cryptococcal meningitis published in the New England Journal of Medicine has shown that a single high-dose infusion of liposomal amphotericin B (10mg/Kg) was non-inferior to one week of conventional amphotericin B, plus oral therapy with flucytosine and fluconazole for 2 weeks in both arms. Professor Joe… Read more »

Fatal Fungal Lung infection affects TB recovered patients due to misdiagnosis; experts call for steps to be taken

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The Global Action For Fungal Infections (GAFFI) is calling for improved diagnostic capability for chronic pulmonary aspergillosis (CPA) – especially Aspergillus antibody detection, as well as antifungal therapy. The call is in response to published studies in India and Vietnam that found over the last 12 months1,2 over 50% of patients cured of TB but… Read more »

GAFFI’s David Denning featured in The Conversation, raising awareness of fungal disease and its impact on Aids-related deaths around the world

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  GAFFI’s Chief Executive, Professor David Denning, recently authored an article in the research and analysis publication, The Conversation focusing on the devastating effect fungal disease has on those with Aids. See the article here   Professor David Denning said: “As more and more people are treated for HIV infection, deaths will continue to come… Read more »

Diagnosis of aspergillosis now routine with good performance – if tests are requested

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On World Aspergillosis Day, GAFFI highlights the significant strides forward in the diagnosis of all forms of aspergillosis over the last few years. Major advances include: Introduction of lateral flow assays for Aspergillus antigen Introduction of lateral flow assay for Aspergillus antibody Determination of cut-offs for Aspergillus antibody for multiple tests and countries The increased… Read more »