One of GAFFI’s priority diseases is fungal (mycotic) keratitis, which leaves 100,000’s blind in at least one eye each year. Professor Matthew Burton is a Wellcome Trust funded clinical researcher focused on corneal infection. He brings deep expertise in to GAFFI in microbial keratitis, with years of experience in Africa and many international collaborations. Matthew… Read more »
University of Manchester researchers have co-ordinated a ‘first of its kind’ series, published today in the prestigious journal The Lancet Infectious Diseases.The series of papers gives new insights into the breadth of fungal diseases and a call to action for world health bodies to prevent millions of infections each year. Killing over 1.5 million and… Read more »
At the International AIDS Society conference in Paris today, Sile Molloy from St George’s Hospital Medical School in London presented the ACTA study results: the largest ever study of cryptococcal meningitis. 678 evaluable patients from 9 sites in 4 African countries were randomized into an all oral regimen of fluconazole (1200mg/d) and flycytosine (100mg/d), amphotericin… Read more »
In a 440 patients study in Vietnam, Dr Thuy Le and colleagues show that conventional amphotericin B is superior to itraconazole for the treatment of talaromycosis in AIDS. Their paper published this month in the New England Journal of Medicine, finds not difference in 2 week mortality (6,2%), but a substantially higher mortality at 24… Read more »
GAFFI (Global Action For Fungal Infection) today welcomes news from the World Health Organisation (WHO) that it has classed the disease known as chromoblastomycosis – a disfiguring fungal disease of poor farmers in South America, Africa, and Asia – as a neglected tropical disease (NTD). Chromoblastomycosis also known as chromomycosis, is one of the most… Read more »
International HIV experts on fungal meningitis in AIDS report finding nearly 250,000 cases annually, 73% in sub-Saharan Africa. Fungal meningitis due to the Cryptococcus fungus typically affects those in the prime of life, 35 years old, and affects the tissues covering the brain and spinal cord. Of those affected an estimated 181,000 people die, despite… Read more »
For the fourth year running, multiple country burdens of fungal diseases have been presented at ECCMID; 4 countries covering a population of 351 million people. The remarkable findings were: The annual incidence of candidaemia in Italy is 24/100,000 and was estimated at 5/100,000 for Belarus, Cameroon and Indonesia, in the absence of data. Cryptococcal meningitis… Read more »
Itraconazole, voriconazole and natamycin 5% ophthalmic preparation ruled as ‘essential antifungals’ GAFFI (Global Action Fund for Fungal Infections) says today’s announcement that three drugs capable of reducing deaths in hundreds of thousands of people worldwide have been given essential medicines status is a Red Letter Day in the fight to reduce blindness and save lives…. Read more »
GAFFI ANNUAL REPORT ON FUNGAL DISEASES: HIGHLIGHTS PROGRESS BUT SCALE OF GLOBAL WORK STILL TO BE DONE GAFFI (Global Action Fund for Fungal Infections) has published its third annual report demonstrating progress made in its mission to reduce illness and death associated with fungal disease worldwide. A new model for reducing illness and death from… Read more »
Estimates never before attempted show the number of people affected by serious fungal diseases in 14 of the worst affected countries across the globe have just been published *. Experts believe they give a stark reminder of the huge disconnect between the lack of fungal public health programs worldwide and the wealth of scientific research… Read more »
