While leading the US Centre for Disease Control and Prevention (CDC) Mycotic Disease Branch, Dr Chiller has been very active in promoting rapid screening for cryptococcal meningitis and disseminated histoplasmosis in people with Advanced HIV Disease. He and his colleagues at CDC have collated US and global data on the multi-resistant fungus Candida auris and… Read more »
The world’s largest randomised study of HIV-positive adults with cryptococcal meningitis published in the New England Journal of Medicine has shown that a single high-dose infusion of liposomal amphotericin B (10mg/Kg) was non-inferior to one week of conventional amphotericin B, plus oral therapy with flucytosine and fluconazole for 2 weeks in both arms. Professor Joe… Read more »
The Global Action For Fungal Infections (GAFFI) is calling for improved diagnostic capability for chronic pulmonary aspergillosis (CPA) – especially Aspergillus antibody detection, as well as antifungal therapy. The call is in response to published studies in India and Vietnam that found over the last 12 months1,2 over 50% of patients cured of TB but… Read more »
GAFFI’s Chief Executive, Professor David Denning, recently authored an article in the research and analysis publication, The Conversation focusing on the devastating effect fungal disease has on those with Aids. See the article here Professor David Denning said: “As more and more people are treated for HIV infection, deaths will continue to come… Read more »
On World Aspergillosis Day, GAFFI highlights the significant strides forward in the diagnosis of all forms of aspergillosis over the last few years. Major advances include: Introduction of lateral flow assays for Aspergillus antigen Introduction of lateral flow assay for Aspergillus antibody Determination of cut-offs for Aspergillus antibody for multiple tests and countries The increased… Read more »
January 30th is Global Neglected Tropical Diseases (NTD) Day. This is a worldwide campaign to raise awareness of these often-overlooked conditions. World NTD Day serves as a call to action to secure increased resources for neglected tropical diseases, and crucially facilitate political leadership and ownership of NTD programs from affected countries. The 2021 Neglected Tropic… Read more »
Exposure to Histoplasma in the air is common in Guatemala (as in many other countries). In ASI ‘s* diagnostic program in collaboration with GAFFI, more and more patients tested positive for disseminated histoplasmosis as more samples were sent. Narda Medina and colleagues report that in 2017, 1836 people with HIV infection were screened and 120 (6.5%)… Read more »
A study of tuberculosis patients in six Jakarta hospitals has revealed up to 13% of them had fungal lung infection – or aspergillosis – at the end of their treatment. The findings could, warn the research team from Universitas Indonesia and The University of Manchester, have implications globally wherever TB is found. The study tracked… Read more »
On World AIDS Day, experts call for global commitment towards the purchasing of diagnostic tests for Pneumocystis pneumonia (PCP), a respiratory fungal infection responsible for a high proportion of deaths among HIV positive children and adults in Africa. A recent survey conducted by GAFFI assessing the availability of WHO listed essential diagnostics for fungal diseases… Read more »
An international panel of experts is calling on global health organisations like the WHO to classify Talaromycosis as a Neglected Tropical Disease (NTD). Shanti Narayanasamy, working with Thuy Le at the Duke University School of Medicine, has summarised the strong arguments in favour of NTD designation in a paper in Lancet Global Health, found here… Read more »
