Posts By: ElBradsh

  Writing in PLoS Neglected Tropical Diseases, Marcio Rodrigues and Joshua Nosanchuk highlight the numerous reasons why fungal diseases are so neglected. They point to a science failure – including inadequate funding. They detail research funding for different diseases by numbers of deaths: malaria $1,315 , tuberculosis $334, diarrhoeal diseases $276, compared with $31 for… Read more »

A recent CDC Morbidity & Mortality Weekly Report estimated the incidence of candidaemia in the US at around 9/100,000 which equates to >28,000 cases annually, with an overall mortality of 25%. 10% of cases are in IV drug abusers, 33% in diabetics and 17% in cancer patients.

The extra cost to save 1 in 5 deaths from cryptococcal meningitis in AIDS is $973 according to Tinevimbo Shiri and colleagues. Using data from the ACTA trial, and assuming 14 days dual therapy with fluconazole and flucytosine, mortality falls from 53.8% to 35.1% over 10 weeks, and more over the following weeks. The additional… Read more »

Estimates of the incidence and prevalence of fungal infections were presented this week at TIMM2019 (Nice, France) for a further 5 countries: Morocco, Sudan, Cote d’Ivoire, Tajikistan and Azerbaijan.

An ad hoc panel of twenty three international medical experts from the fields of mycology, microbiology and dermatology, led by the International Foundation for Dermatology (IFD) and Global Action Fund for Fungal Infections (GAFFI), have put forward methods for developing essential diagnostic strategies for three major skin Fungal Neglected Tropical Diseases (NTDs). You can find… Read more »

Researchers from Manchester (UK) and Jakarta (Indonesia) have published new prevalence data for histoplasmosis exposure for multiple countries in SE Asia. Sensitivity to the histoplasmin skin test was seen in a large proportion of the population (26-86%), so it is likely that rolling out the Histoplasma antigen test (now on the WHO Essential Diagnostics List) will help to diagnose cases and save lives.

The World Health Organisation has updated its Essential Medicines List to the Histoplasma antigen test, which can be used on urine to diagnose histoplasmosis in 48 hours. Rolling out this test worldwide could save up to 48,000 lives in 5 years.

Lateral flow rapid diagnostics are sorely needed for many fungal infections. Scientists at the University of Manchester evaluated LDBio’s Aspergillus IgG test on patients at the National Aspergillosis Centre (UK). Compared to existing diagnostics, this test was more sensitive (91.6%) and more specific (98.0%) for chronic pulmonary aspergillosis.

Over 1.1 million cases of fungal keratitis are documented annually, leading to >100,000 perforated or surgically removed eyes and >500,000 blind eyes, according to a team from the University of Manchester, London School of Hygiene and Tropical Medicine and GAFFI. Lottie Brown presented this systematic review at Europe’s premier infection meeting ECCMID (Amsterdam) earlier this… Read more »